Place related information in proximity, and separate unrelated information with white space, rules, and borders.
In the flyer below, the first two blocks of information both have subheadings in 18-point Helvetica, making them of equal importance, but the white space between the blocks makes it obvious that they're unrelated.
Bullet items appear beneath each subheading, calling attention to the individual points, and their proximity shows that they're closely related. Finally, at the bottom of the flyer, the company name is placed in proximity to the address and phone number because those are all related elements.
By first grouping related information and then separating the groups with white space, rules, or borders, you organize information and make the reader's job easier.